What is the NS1/IgM/IgG combotest used for?

Table of Contents

1. Introduction
2. Understanding the NS1/IgM/IgG Combo Test
3. Components of the NS1/IgM/IgG Combo Test
4. Applications of the NS1/IgM/IgG Combo Test
5. Performance Parameters and Numerical Analysis
6. QL Biotech Company Solutions
7. Conclusions
8. References

Introduction

The NS1/IgM/IgG Combo Test is a critical diagnostic tool used in the identification of viral infections, particularly dengue fever. Combining antigen and antibody testing, this test enhances the diagnostic accuracy and provides comprehensive insights into the patient's immune response to the infection.

Understanding the NS1/IgM/IgG Combo Test

The NS1/IgM/IgG Combo Test is designed to detect NS1 antigen along with IgM and IgG antibodies specific to dengue virus. The NS1 antigen is a non-structural protein found in the early stages of infection, while IgM and IgG are antibodies that indicate different phases of immune response.

Components of the NS1/IgM/IgG Combo Test

This test comprises three primary components:

• NS1 Antigen Detection: Useful for early detection, within the first 1-7 days of infection.
• IgM Antibody Detection: Indicates recent infection, appearing as early as 3-5 days post onset.
• IgG Antibody Detection: Indicates past exposure, typically detectable after 7-10 days post onset.

Applications of the NS1/IgM/IgG Combo Test

This combo test is crucial in endemic regions for the following purposes:

• Early diagnosis of dengue fever
• Assessment of the stage of infection
• Evaluation of past exposures and potential immunity

Performance Parameters and Numerical Analysis

Key performance metrics of the NS1/IgM/IgG Combo Test include:

• Sensitivity: NS1 has a sensitivity range of 70-90% in early infection.
• Specificity: The test shows specificity values ranging from 95-98% for NS1 detection.
• Accuracy: Combined accuracy for IgM/IgG is approximately 85-90%.
• Time to Result: Results are typically available within 15-30 minutes.

QL Biotech Company Solutions

QL Biotech provides innovative solutions in the form of rapid diagnostic test kits that incorporate advanced technology for enhanced sensitivity and specificity. Their solutions include:

• Optimized assay methods for improved detection rates
• Cost-effective solutions ensuring broader accessibility
• Compact designs suitable for field use and mass screening

Conclusions

The NS1/IgM/IgG Combo Test is an invaluable tool in the fight against dengue fever, providing vital information that guides treatment decisions and public health interventions. With advancements from companies like QL Biotech, the efficacy and accessibility of these tests continue to improve, contributing to better healthcare outcomes.

References

• Smith, J. et al. (2020). Dengue Diagnostics: Evaluation of the NS1/IgM/IgG Combo Test. Journal of Clinical Virology, 128, 104-110.
• World Health Organization. (2019). Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control.
• QL Biotech Inc. (2023). Product Brochure: Advanced Dengue Diagnostic Solutions.